API Chlormadinone Acetate CMA 302-22-7 Estrogen Female Hormones

Short Description:

Chlormadinone acetate is a progestin and antiandrogen medication which is used in birth control pills to prevent pregnancy, as a component of menopausal hormone therapy, in the treatment of gynecological disorders, and in the treatment of androgen-dependent conditions like enlarged prostate and prostate cancer in men and acne and hirsutism in women.

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Product Detail

Product Tags

Description

Chlormadinone acetate (CMA) is a potent progesterone receptor (PR) agonist, a partial androgen receptor (AR) antagonist and a weak glucocorticoid receptor (GR) antagonist. Chlormadinone binds to PRs, which induces the expression of progesterone -responsive genes.

Specification:

Product Name	Chlormadinone acetate
Chemical Name	17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione
Other Name	Clormadinoneacetate;chloromadinone17-acetate;6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione;17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione,6-Chloro-6-dehydro-17α-acetoxyprogesterone,Gestafortin,Matrol,Menstridyl,6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione17-acetate;17-alpha-acetoxy-;ChChemicalbooklormadinoneacetate,17α-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione,6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione17-acetate,6-Chloro-6-dehydro-17α-acetoxyprogesterone,Gestafortin,Matrol,Mens;(8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-diMethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylacetate
CAS Number	302-22-7
Molecular Formula	C23H29ClO4
Formula Weight	404.93
Appearance	White To Yellowish Crystalline Powder; Odorless, Tasteless
Assay	98.0% min
Melting Point	212°C
Boiling Point	512.5±50.0 °C
Absorption Peak	1.1345 g/cm3
Package	20kg/bag/drum, 25kg/bag/drum, or as you required
Storage	Store the container tightly closed in a dry & cool place. Do not expose to direct sunlight.
COA & MSDS	Available
Application	For research purpose

Certificate of Analysis/COA:

TEST	ACCEPTANCE CRITERIONS	RESULTS
Identification	TLC	Positive
	UV spectrum	Positive
	IR spectrum	Positive
Characteristics	White or yellowish crystalline powder	conform
Melting point	211 ~ 215℃	211~214℃
Specific optical rotation	﹣10° ~﹣14°	﹣12.5°
Solubility	freely soluble in chloroform,soluble in acetonitrile,slightly soluble in ethanol and ether and pratcically insoluble in water.	conform
Loss on drying	≤0.5%	0.21%
Residue on ignition	≤0.1%	0.04%
Other steroids	≤1.0%	0.59%
Heavy metals	≤20ppm	Pass
Arsenic	≤2ppm	Pass
Assay	≥98.0%	98.9%
Residual solverts(GC)	Acetone ≤5000ppm Methanol≤3000ppm Pyridine≤200ppm	Pass Pass Pass