API Donepezil HCl CAS 120011-70-3 For Alzheimer’S Disease

Short Description:

Donepezil Hydrochloride is the hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity.

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Product Detail

Product Tags

Description

Donepezil is used to treat confusion related to Alzheimer's disease.

Specification:

Product Name	Donepezil Hydrochloride
Chemical Name	1h-inden-1-one,2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)me
Other Name	Donepezil hcl;Donezepilhydrochloride;DonepezilHydrochloride(200mg);2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-onehydrochloride;2,3-Dihydro-5,6-diMetChemicalbookhoxy-2-[[1-(phenylMethyl)-4-piperidinyl]Methyl]-;2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanoneHydrochloride;Donepezil(Aricept);DonepezilHydrochlorideForMⅠ
CAS Number	120011-70-3
Molecular Formula	C24H30ClNO3
Formula Weight	415.95
Appearance	White to off-white crystalline solid
Assay	98.0% min
Melting Point	220-222 °C
Boiling Point	527.9 C At 760 MmHg
Package	20kg/bag/drum, 25kg/bag/drum, or as you required
Storage	Store the container tightly closed in a dry & cool place. Do not expose to direct sunlight.
COA & MSDS	Available
Application	For research purpose

Certificate of Analysis/COA:

TEST ITEM	SPECIFICATION	RESULT
Appearance	Off white to white crystalline powder	Complies
Solubility	Freely soluble in chloroform, soluble in water and Acetic acid, slightly soluble in Acetonitrile and ethanol, insoluble in Ethylacetoacetate and n-hexane.	Complies
Identification	(1)By IR absorption ,To match with working standard.	Complies
	(2) The retention time of the major peak of the sample should accord with that of the working standard.	Complies
	(3) Test for chlorides. Reponds to the test for Chlorides.	Complies
Water	≤0.4%	0.31%
Residue on ignition	≤0.1%	0.02%
Related substance	Desbenzyl donepezl^a≤0.15% Donepezil pyridine analog^b≤0.15% Donepezilzilbenzyl bromide^c≤0.15% Dehydrodeoxy donepezil^d≤0.15% Deoxy donepezil^e≤0.15% Any Unkonwn single impurity≤0.10% Total ≤0.5%	Not detected Not detected 0.02% Not detected Not detected 0.05% 0.18%
Heavy metal	≤20ppm	≤20ppm
Residual Solvents	Methanol≤0.3%Ethanol≤0.5%Ethyl acetate≤0.5% Toluene≤0.089% Acetic acid≤0.5%	Not detected Not detected Not detected Not detected Not detected
Assay	On dried base, C₂₄H₂₉NO₃·HCl should be 98.0% to 102.0%.	99.52%